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Benserazide (hydrochloride) (Standard)

Benserazide hydrochloride (Standard) (Serazide (Standard) ) is the analytical standard of Benserazide hydrochloride. This product is intended for research and analytical applications. Benserazide hydrochloride (Serazide) is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide hydrochloride is also a PKM2 inhibitor. Benserazide hydrochloride directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide hydrochloride can be used for the study of Parkinson's disease and melanoma[1][2][3].

Product Specifications

CAS Number

14919-77-8

Product Name Alternative

Ro 4-4602 (hydrochloride) (Standard)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Pyruvate Kinase; Reference Standards

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/benserazide-hydrochloride-standard.html

Purity

99.89

Smiles

NC(C(NNCC1=CC=C(C(O)=C1O)O)=O)CO.Cl

Molecular Formula

C10H16ClN3O5

Molecular Weight

293.70

Precautions

H315, H319, H335

References & Citations

[1]Shen H, et al. Effects of benserazide on L-DOPA-derived extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats. Tohoku J Exp Med. 2003 Mar;199 (3) :149-59.|[2]Chandel TI, et al. A multiparametric analysis of the synergistic impact of anti-Parkinson's drugs on the fibrillation of human serum albumin. Biochim Biophys Acta Proteins Proteom. 2019 Mar;1867 (3) :275-285.

Shipping Conditions

Blue Ice

Storage Conditions

4°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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