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ZAP70 Antibody (Phospho-Tyr493)

Product Specifications

CAS Number

9007-83-4

Gene Name

Zeta chain of T cell receptor associated protein kinase 70kDa

Gene Aliases

SRK, STD, TZK, STCD, IMD48, ADMIO2, ZAP-70

Gene ID

7535

Swiss Prot

P43403

Accession Number

NP_001070.2

Reactivity

Human, Mouse, Rat

Immunogen

A phospho-Serpecific peptide corresponding-Thro residues-Serurrounding-Tyr493 of human ZAP70

Target

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Polyclonal Antibody

Applications

WB, IHC

Purification

Affinity purified against immunogen

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Format

Liquid

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Reconstitution

Store at -20C. Avoid repeated freeze/thaw cycles.

Molecular Weight

70 kDa

Fragment

IgG

NCBI Gene Symbol

ZAP70

Host or Source

Rabbit

Protein Name

Tyrosine-protein kinase ZAP-70

Gene Name URL

ZAP70

Nucleotide Accession Number

NM_001079.3

Frequently Asked Questions

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