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NOTCH3 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Notch 3

Gene Aliases

IMF2, LMNS, CASIL, CADASIL, CADASIL1

Gene ID

4854

Swiss Prot

Q9UM47

Accession Number

NP_000426.2

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human NOTCH3

Target

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Polyclonal Antibody

Applications

WB, IHC, IF

Purification

Affinity purification.

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Format

Liquid.// PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

Reconstitution

Store at -20C. Avoid repeated freeze/thaw cycles.

Molecular Weight

244 kDa

Fragment

IgG

NCBI Gene Symbol

NOTCH3

Host or Source

Rabbit

Protein Name

Neurogenic locus notch homolog protein 3

Gene Name URL

NOTCH3

Nucleotide Accession Number

NM_000435.2

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