Acanthifolicin
Product Specifications
CAS Number
77739-71-0
UNSPSC Description
Acanthifolicin, a derivative of Okadaic acid (HY-N6785), is a protein phosphatase inhibitor. Acanthifolicin inhibits protein phosphatase-1 (PP1) and PP2 with IC50 values of 20 nM and 1 nM, respectively[1].
Target Antigen
Phosphatase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/acanthifolicin.html
Smiles
OC([C@@](C)(C[C@@H](O[C@]12[C@H]3S[C@@]3(C[C@H](O2)[C@@H](/C=C/[C@@H]4O[C@@]5(CC4)CC[C@@H]6[C@@H](O5)[C@@H](C([C@H]([C@@H](C[C@@H]([C@H]7O[C@]8(OCCCC8)CC[C@H]7C)C)O)O6)=C)O)C)C)CC[C@H]1O)O)=O
Molecular Weight
837.07
References & Citations
[1]Holmes CF, et al. Inhibition of protein phosphatases-1 and -2A with acanthifolicin. Comparison with diarrhetic shellfish toxins and identification of a region on okadaic acid important for phosphatase inhibition. FEBS Lett. 1990 Sep 17;270(1-2):216-8.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Frequently Asked Questions
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