HMGCR Antibody
Product Specifications
Gene Aliases
LDLCQ3
Gene ID
3156
Swiss Prot
P04035
Accession Number
NP_000850
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human HMGCR.
Target
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
WB, IHC
Purification
The antiserum was purified by peptide affinity chromatography
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/mL
Format
Liquid.// PBS pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Reconstitution
Store at -20° C. Stable for 12 months from date of receipt._x005F
Molecular Weight
95 kDa
Fragment
IgG
Specificity
HMGCR Ab detects endogenous levels of total HMGCR.
NCBI Gene Symbol
HMGCR
Host or Source
Rabbit
Protein Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name URL
HMGCR
CAS Number
9007-83-4
Nucleotide Accession Number
NM_000859
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