HTR1B Antibody
Product Specifications
CAS Number
9007-83-4
Gene Aliases
S12, 5-HT1B, HTR1D2, HTR1DB, 5-HT-1B, 5-HT1DB, 5-HT-1D-beta
Gene ID
3351
Swiss Prot
P28222
Accession Number
NP_000854
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human 5HT1B Receptor, corresponding to a region with the internal amino acids.
Target
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) . Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD) . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.1
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
WB, IF, ICC, P-ELISA
Purification
Purified by peptide affinity chromatography.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/mL
Format
Liquid// PBS (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol
Reconstitution
Store at -20° C. Stable for 12 months from date of receipt.
Molecular Weight
48 kDa
Fragment
IgG
Specificity
5HT1B Receptor Antibody detects endogenous levels of total 5HT1B Receptor.
NCBI Gene Symbol
HTR1B
Host or Source
Rabbit
Protein Name
5-hydroxytryptamine receptor 1B
Gene Name URL
HTR1B
Nucleotide Accession Number
NM_000863
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