EIF2AK2 Antibody (Phospho-Thr446)
Product Specifications
CAS Number
9007-83-4
Gene Name
Eukaryotic translation initiation factor 2-alpha kinase 2
Gene Aliases
PKR, PRKR, LEUDEN, EIF2AK1, PPP1R83
Gene ID
5610
Swiss Prot
P19525
Reactivity
Human
Immunogen
A synthesized peptide derived from human PKR around the phosphorylation site of Thr446
Target
PKR a protein kinase of the PEK family. Upon binding doublestranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
WB, IF, ICC, IHC
Purification
The Ab is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and nonphospho-peptide affinity columns.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid.// PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Reconstitution
Store at -20° C. Stable for 12 months from date of receipt.
Molecular Weight
74 kDa
Specificity
Phospho-PKR (Thr446) Ab detects endogenous levels of PKR only when phosphorylated at Threonine 446
NCBI Gene Symbol
EIF2AK2
Host or Source
Rabbit
Gene Name URL
EIF2AK2
Frequently Asked Questions
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