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Midaglizole (hydrochloride)

Midaglizole hydrochloride ((±) -DG5128, DG5128) is a potent α2-adrenoceptor antagonist. Midaglizole hydrochloride is a hypoglycemic agent. Midaglizole hydrochloride increases blood pressure and reduces blood glucose levels in vivo[1][2][3].

Product Specifications

CAS Number

79689-25-1

Product Name Alternative

(±) -DG5128; DG5128

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/DG5128.html

Purity

99.67

Solubility

DMSO : 500 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C(C1=CC=CC=C1)(C2=CC=CC=N2)CC3=NCCN3.Cl

Molecular Formula

C16H19Cl2N3

Molecular Weight

324.25

References & Citations

[1]Proks P, et al. Inhibition of recombinant K (ATP) channels by the antidiabetic agents midaglizole, LY397364 and LY389382. Eur J Pharmacol. 2002 Sep 27;452 (1) :11-9.|[2]Hirohashi M, et al. Intrinsic pressor activity of midaglizole, an alpha-2 adrenoceptor antagonist, in pithed rats. Jpn J Pharmacol. 1990 Aug;53 (4) :519-20.|[3]Ohneda K, et al. Mechanism of insulin secretion by midaglizole. Diabetes Res Clin Pract. 1993 Feb;19 (2) :127-32.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

α adrenergic receptor

Available Sizes

Frequently Asked Questions

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