What is the catalog number for Anti-TGF- Beta R1 Polyclonal Antibody?

The catalog number for Anti-TGF- Beta R1 Polyclonal Antibody is OAAI00094-100UG.

What sizes are available for Anti-TGF- Beta R1 Polyclonal Antibody?

Anti-TGF- Beta R1 Polyclonal Antibody is available in the following size(s): 100 µg.

Is Anti-TGF- Beta R1 Polyclonal Antibody in stock?

Anti-TGF- Beta R1 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

Anti-TGF- Beta R1 Polyclonal Antibody

Transforming growth factor beta isoforms (TGF-beta1, 2, 3) play vital roles in regulating cellular growth and differentiation, and they signal through a highly restricted subset of receptors known as TGF-beta type I receptor (T-betaR-I) and TGF-beta type II receptor (T-beta-R-II) . Expression of T beta R-I is more ubiquitous than that of T beta R-II. There was no staining of T beta R-II in the central nervous system, while intense T beta R-I staining was found specifically in nervous tissues. Expression of T beta R-I and T beta R-II was mostly coincident with that of their ligands, suggesting that TGF-beta s act as multiple mediators during organogenesis. TGF-beta binds with high affinity to its receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain, to form a dynamic dimer with phosphorylation in the cytoplasmic Ser/Thr residuals which cause its kinase activity and association with another TGF beta-binding protein, the type I receptor, to signal growth inhibition and early gene responses.

Product Specifications

CAS Number

9007-83-4

Gene Name

Transforming growth factor beta receptor 1

Gene Aliases

AAT5; activin A receptor type II-like kinase, 53kDa; activin A receptor type II-like protein kinase of 53kD; activin receptor-like kinase 5; ACVRLK4; ALK5; ALK-5; ESS1; LDS1; LDS1A; LDS2A; MSSE; mutant transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; SKR4; tbetaR-I; TBR-i; TBRI; TGF-beta receptor type-1; TGFR-1; transforming growth factor beta receptor I; transforming growth factor-beta receptor type I.

Gene ID

7046

Swiss Prot

P36897

Reactivity

Human|Mouse|Rat

Immunogen

A synthetic peptide of human TGFbR1

Target

Transforming growth factor beta isoforms (TGF-beta1, 2, 3) play vital roles in regulating cellular growth and differentiation, and they signal throμ gh a highly restricted subset of receptors known as TGF-beta type I receptor (TbetaR-I) and TGF-beta type II receptor (TbetaR-II) . TGF-beta's specificity for TbetaR-I has been proposed to arise from its pre-helix extension, a five-residue loop that binds in the cleft between TGF-beta and TbetaR-II. TGF-beta binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain, which requires both its kinase activity and association with another TGF beta-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGF beta, and receptor II requires receptor I to signal. Mutations in TbetaR-I and TbetaR-II gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS) .

Clonality

Polyclonal

Type

Polyclonal Antibody

Applications

Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry|Immunoprecipitation|Western blot

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Format

Liquid. This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer

Reconstitution

The antibodies are stable for 24 months from date of receipt when stored at -20° C to -70° C. The antibodies can be stored at 2-8° C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.