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TIMP1 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

TIMP metallopeptidase inhibitor 1

Gene Aliases

EPA, EPO, HCI, CLGI, TIMP, TIMP-1

Gene ID

7076

Swiss Prot

P01033

Accession Number

NP_003245.1

Immunogen

The antiserum was produced against synthesized peptide derived between 80-120 aa of human TIMP1. The exact sequence is proprietary.

Target

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Clonality

Monoclonal

Clone

ABT-TIMP1

Type

Monoclonal Antibody

Applications

IHC-P

Purification

Immunogen affinity purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Format

Liquid. Supplied in 1% BSA, 0.05M Tris-HCl, 0.15M NaCl, 0.2% Kathon CG/ICP, 0.1% Tween-20

Reconstitution

Shipped at 4C. Store at -20C. Stable for 12 months at -20C.

Molecular Weight

23 kDa

Fragment

IgG

Specificity

Anti-Tissue Inhibitor of Metalloproteinases 1 (TIMP1) [ABT-TIMP1] detects endogenous levels of total Tissue Inhibitor of Metalloproteinases 1 (TIMP1) protein.

NCBI Gene Symbol

TIMP1

Host or Source

Mouse

Protein Name

Metalloproteinase inhibitor 1

Gene Name URL

TIMP1

Nucleotide Accession Number

NM_003254.2

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