WT1 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
WT1 transcription factor
Gene Aliases
AWT1; GUD; NPHS4; WAGR; Wilms tumor 1; Wilms tumor protein; WIT-2; WT33.
Gene ID
7490
Swiss Prot
P19544
Accession Number
NP_000369.3
Reactivity
Human
Immunogen
Synthetic peptide
Target
Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533) . Recognizes and binds to the DNA sequence 5'-GCG (T/G) GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363) . Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190) . Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801) . Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921) .
Clonality
Monoclonal
Clone
ABT-WT1
Type
Monoclonal Antibody
Applications
Immunohistochemistry
Purification
Immunogen affinity purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Format
PBS, pH7.2, 0.03% Proclin 300, 50% glycerol
Reconstitution
-20°C
Molecular Weight
55 kDa
Fragment
IgG
Specificity
Anti-Wilms' Tumor 1 (WT1) [ABT-WT1] detects endogenous levels of total Wilms' Tumor 1 (WT1) protein.
NCBI Gene Symbol
WT1
Host or Source
Mouse
Protein Name
Wilms tumor protein
Gene Name URL
WT1
Nucleotide Accession Number
NM_001198551.1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
