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KRT17 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Keratin 17

Gene Aliases

39.1; CK-17; cytokeratin-17; K17; keratin 17, type I; keratin, type I cytoskeletal 17; Keratin-17; PC; PC2; PCHC1.

Gene ID

3872

Swiss Prot

Q04695

Accession Number

NP_000413.1

Reactivity

Human

Immunogen

Synthetic peptide

Target

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity) . Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity) . Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity) . Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity) . May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Clonality

Monoclonal

Clone

ABT-CK17

Type

Monoclonal Antibody

Applications

Immunohistochemistry, Western blot

Purification

Immunogen affinity purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Format

PBS, pH7.2, 0.03% Proclin 300, 50% glycerol

Reconstitution

-20°C

Molecular Weight

48 kDa

Fragment

IgG

Specificity

Anti-Cytokeratin 17 [ABT-CK17] detects endogenous levels of total Cytokeratin 17 protein.

NCBI Gene Symbol

KRT17

Host or Source

Mouse

Protein Name

Keratin, type I cytoskeletal 17

Gene Name URL

KRT17

Nucleotide Accession Number

NM_000422.2

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