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Bazedoxifene

Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].

Product Specifications

CAS Number

[198481-32-2]

Product Name Alternative

TSE-424

UNSPSC

12352005

Hazard Statement

H360

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bazedoxifene.html

Concentration

10mM

Purity

99.35

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OCCN4CCCCCC4)C=C3)C5=CC=C(O)C=C51

Molecular Formula

C30H34N2O3

Molecular Weight

470.60

Precautions

H360

References & Citations

[1]Barry S Komm, et al. Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology. 2005 Sep;146 (9) :3999-4008.|[2]Xiaojuan Wu, et al. Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. Mol Cancer Ther. 2016 Nov; 15 (11) : 2609–2619.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Arch Biochem Biophys. 2025 Jun:768:110366.|biorxiv. 2024 May 21.|Breast Cancer Res Treat. 2020 Jan;179 (1) :67-77.|Eur J Pharmacol. 2023 May 15:947:175681.|Free Radic Biol Med. 2023 Aug 20:205:163-174.|Glia. 2023 Feb;71 (2) :284-304.|Gynecol Oncol. 2019 Jul;154 (1) :199-206.|J Cell Biochem. 2023 Sep;124 (9) :1404-1422.|Res Sq. 2020 Dec 31:rs.3.rs-100914.|Research Square Preprint. 2022 Jul.|University of Colorado Denver. 2024.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|J Med Chem. 2020 Oct 8;63 (19) :11085-11099.|mSphere. 2020 Apr 8;5 (2) :e00124-20.

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