CMTM6 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
CKLF like MARVEL transmembrane domain containing 6
Gene Aliases
Chemokine-like factor super family 6; chemokine-like factor superfamily 6; chemokine-like factor superfamily member 6; CKLF-like MARVEL transmembrane domain-containing protein 6; CKLFSF6; PRO2219.
Gene ID
54918
Swiss Prot
Q9NX76
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human CMTM6.
Target
Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
TSAEIAAIVFGFIASFMFLLDFITMLYEKRQESQLRKPENTTRAEALTEP
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using peptide.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1mg/ml
Reconstitution
-20°C
Molecular Weight
20 kDa
Specificity
CMTM6 Antibody detects endogenous levels of CMTM6 protein.
NCBI Gene Symbol
CMTM6
Host or Source
Rabbit
Protein Name
CKLF-like MARVEL transmembrane domain-containing protein 6
Gene Name URL
CMTM6
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