WNK1 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
WNK lysine deficient protein kinase 1
Gene Aliases
Erythrocyte 65 kDa protein; HSAN2; HSN2; KDP; Kinase deficient protein; p65; PPP1R167; PRKWNK1; prostate-derived sterile 20-like kinase; Protein kinase lysine-deficient 1; protein kinase with no lysine 1; protein phosphatase 1, regulatory subunit 167; PSK; serine/threonine-protein kinase WNK1; serine/threonine-protein kinase WNK1 1; serine/threonine-protein kinase WNK1 2.
Gene ID
65125
Swiss Prot
Q9H4A3
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human WNK1.
Target
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
APKNGSSSDSSVGEKLGAAAADAVTGRTEEYRRRRHTMDKDSRGAAATTT
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Purification
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1mg/ml
Reconstitution
-20°C
Molecular Weight
250 kDa
Notes
Formerly GWB-ASC113
Specificity
WNK1 Antibody detects endogenous levels of total WNK1 protein.
NCBI Gene Symbol
WNK1
Host or Source
Rabbit
Protein Name
Serine/threonine-protein kinase WNK1
Gene Name URL
WNK1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1091444-01 0.02 mg (E-Coli)
Recombinant Bacillus cereus Elongation factor Tu (tuf)
Ask
View Details 
MBS1091444-02 0.02 mg (Yeast)
Recombinant Bacillus cereus Elongation factor Tu (tuf)
Ask
View Details 
MBS1091444-03 0.1 mg (E-Coli)
Recombinant Bacillus cereus Elongation factor Tu (tuf)
Ask
View Details MBS1091444-04 0.1 mg (Yeast)
Recombinant Bacillus cereus Elongation factor Tu (tuf)
Ask
View Details MBS1091444-05 0.02 mg (Baculovirus)
Recombinant Bacillus cereus Elongation factor Tu (tuf)
Ask
View Details MBS1091444-06 0.02 mg (Mammalian-Cell)
Recombinant Bacillus cereus Elongation factor Tu (tuf)
Ask
View Details