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GPR143 Antibody

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Product Specifications

CAS Number

9007-83-4

Gene Name

G protein-coupled receptor 143

Gene Aliases

G-protein coupled receptor 143; NYS6; OA1; ocular albinism 1; ocular albinism type 1 protein.

Gene ID

4935

Swiss Prot

P51810

Accession Number

NP_000264.2

Reactivity

Human|Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human GPR143.

Target

Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca (2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G (q) -mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.

Clonality

Polyclonal

Type

Polyclonal Antibody

Applications

Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Dilution

The optimal working dilution should be determined by the end user.

Format

Liquid

Reconstitution

-20°C

Molecular Weight

43 kDa

Notes

Formerly GWB-ASF316

Specificity

GPR143 antibody detects endogenous levels of total GPR143 protein.

NCBI Gene Symbol

GPR143

Host or Source

Rabbit

Protein Name

G-protein coupled receptor 143

Gene Name URL

GPR143

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