CYP4F2 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Cytochrome P450 family 4 subfamily F member 2
Gene Aliases
20-HETE synthase;20-hydroxyeicosatetraenoic acid synthase; arachidonic acid omega-hydroxylase; CPF2; CYPIVF2; cytochrome P450 4F2; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 2; cytochrome P450-LTB-omega; docosahexaenoic acid omega-hydroxylase; leukotriene-B (4) 20-monooxygenase 1; leukotriene-B (4) omega-hydroxylase 1; phylloquinone omega-hydroxylase CYP4F2.
Gene ID
8529
Swiss Prot
P78329
Accession Number
NP_001073.3
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human CYP4F2.
Target
Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531) . Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070) . Also acts as a leukotriene-B (4) omega-hydroxylase by mediating conversion of leukotriene-B (4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene-B (4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid
Reconstitution
-20°C
Molecular Weight
59 kDa
Specificity
Cytochrome P450 4F2 antibody detects endogenous levels of total Cytochrome P450 4F2 protein.
NCBI Gene Symbol
CYP4F2
Host or Source
Rabbit
Protein Name
Phylloquinone omega-hydroxylase CYP4F2
Gene Name URL
CYP4F2
Curated Selection
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