CK2 inhibitor 2

CK2 inhibitor 2 is a potent, selective and orally active inhibitor of CK2, with an IC50 of 0.66 nM. CK2 inhibitor 2 shows high selectivity for Clk2 (IC50=32.69 nM) /CK2. CK2 inhibitor 2 exhibits favorable antiproliferative and antitumor activity[1].

Product Specifications

CAS Number

[2641079-92-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Casein Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ck2-inhibitor-2.html

Purity

98.51

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC2=C(C3=CN=CC=C3C(NC4=CC(Cl)=CC=C4)=N2)C=C1)NCCO

Molecular Formula

C21H17ClN4O2

Molecular Weight

392.84

Precautions

H302, H315, H319

References & Citations

[1]Wang Y, et, al. Discovery of 5- (3-Chlorophenylamino) benzo[ c][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition. J Med Chem. 2021 Apr 22;64 (8) :5082-5098.