SEMBL

SEMBL is a potent NF-κB inhibitor. SEMBL can inhibit NF-κB-DNA binding, and also inhibits NF-κB-dependent inflammatory cytokine secretions. SEMBL inhibits cancer cell migration and invasion via decreasing MMP expression. SEMBL can be used for researching anticancer[1].

Product Specifications

CAS Number

[1443448-82-5]

UNSPSC

12352005

Target

MMP; NF-κB

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sembl.html

Purity

99.16

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C1=C)COC1=O)C2=CC=CC=C2O

Molecular Formula

C12H11NO4

Molecular Weight

233.22

References & Citations

[1]Umezawa K, et al. Inhibition of matrix metalloproteinase expression and cellular invasion by NF-κB inhibitors of microbial origin. Biochim Biophys Acta Proteins Proteom. 2020;1868 (6) :140412.