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ABCB11 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

ATP binding cassette subfamily B member 11

Gene Aliases

BSEP, PGY4, SPGP, ABC16, BRIC2, PFIC2, PFIC-2

Gene ID

8647

Swiss Prot

O95342

Accession Number

NP_003733.2

Reactivity

Human, Mouse

Immunogen

This ABCB11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1063-1097 amino acids of human ABCB11.

Target

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

Clonality

Polyclonal

Clone

RB53271

Type

Polyclonal Antibody

Applications

WB

Purification

Protein A column purification, followed by peptide affinity purification

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

500 ug/mL

Homology

Human, Mouse

Format

Liquid

Reconstitution

Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

146 kDa

Fragment

Rabbit Ig

NCBI Gene Symbol

ABCB11

Host or Source

Rabbit

Gene Name URL

ABCB11

Nucleotide Accession Number

NM_003742.2

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