URAT1&XO inhibitor 2
Product Specifications
UNSPSC Description
URAT1&XO inhibitor 2 (Compound BDEO) is a dual inhibitor of xanthine oxidase and URAT1, with IC50 of 3.3 μM for xanthine oxidase. URAT1&XO inhibitor 2 blocks uptake of uric acid in HEK293 cells expressing URAT1, with a Ki value of 0.145 μM. URAT1&XO inhibitor 2 decreases serum urate level and uric acid excretion in hyperuricemic mice. URAT1&XO inhibitor 2 can be used for research of hyperuricemia[1].
Target Antigen
URAT1; Xanthine Oxidase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/urat1-xo-inhibitor-2.html
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
BrC(C=C1)=CC=C1C/C(C2=C(C=C(C=C2)O)O)=N\O
Molecular Weight
322.15
References & Citations
[1]Hu Q, et al. (E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime is a potential therapeutic agent for treatment of hyperuricemia through its dual inhibitory effects on XOD and URAT1. Biomed Pharmacother. 2017 Feb;86:88-94.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153972/URAT1-XO-inhibitor-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153972/URAT1-XO-inhibitor-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1239488-96-0
Available Sizes
Curated Selection
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