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ITPK1 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Aliases

ITRPK1

Gene ID

3705

Swiss Prot

Q13572

Accession Number

NP_001136065.1

Reactivity

Human, Mouse, Bovine

Immunogen

This ITPK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-54 amino acids from the N-terminal region of human ITPK1.

Target

Kinase that can phosphorylate various inositol polyphosphate such as Ins (3,4,5,6) P4 or Ins (1,3,4) P3. Phosphorylates Ins (3,4,5,6) P4 at position 1 to form Ins (1,3,4,5,6) P5. This reaction is thought to have regulatory importance, since Ins (3,4,5,6) P4 is an inhibitor of plasma membrane Ca (2+) -activated Cl (-) channels, while Ins (1,3,4,5,6) P5 is not. Also phosphorylates Ins (1,3,4) P3 on O-5 and O-6 to form Ins (1,3,4,6) P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins (1,3,4,5) P4 and Ins (1,3,4,6) P4 to Ins (1,3,4) P3, and Ins (1,3,4,5,6) P5 to Ins (3,4,5,6) P4. May also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins (1,3,4,5) P4 and Ins (1,3,4,6) P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

Clonality

Polyclonal

Type

Polyclonal Antibody

Applications

WB

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.32 mg/ml

Format

Liquid// PBS with 0.09% (W/V) sodium azide.

Reconstitution

Maintain refrigerated at 2-8° C for up to 2 weeks. For long term storage store at -20° C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

46 kDa

Fragment

Ig

NCBI Gene Symbol

ITPK1

Host or Source

Rabbit

Protein Name

Inositol-tetrakisphosphate 1-kinase

Gene Name URL

ITPK1

Frequently Asked Questions

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