PCO371
PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.
Product Specifications
CAS Number
1613373-33-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
PTHR
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/PCO371.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)OC1=CC=C(C2=NC3(CCN(S(CCC4=C(C)C=C(N5C(NC(C5(C)C)=O)=O)C=C4C)(=O)=O)CC3)C(N2)=O)C=C1
Molecular Formula
C29H32F3N5O6S
Molecular Weight
635.65
Precautions
H302, H315, H319
References & Citations
[1]Tamura T, et al. Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism. Nat Commun. 2016 Nov 18;7:13384.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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