Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SB225002

SB225002, a potent, selective and non-peptide CXCR2 antagonist, inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM.

Product Specifications

CAS Number

182498-32-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CXCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/SB225002.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NC1=CC=C([N+]([O-])=O)C=C1O)NC2=CC=CC=C2Br

Molecular Formula

C13H10BrN3O4

Molecular Weight

352.14

Precautions

H302, H315, H319, H335

References & Citations

[1]White JR, et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem. 1998 Apr 24;273 (17) :10095-8.|[2]Wang B, et al. A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer. Cancer Res. 2006 Mar 15;66 (6) :3071-7.|[3]Herz J, et al. Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice. Stroke. 2015 Oct;46 (10) :2916-25.|[4]Wang LY, et al. CXCL5 signaling is a shared pathway of neuroinflammation and blood-brain barrier injury contributing to white matter injury in the immature brain. J Neuroinflammation. 2016 Jan 6;13:6.|[5]Shi ZR, et al. Decrease of galectin-3 in keratinocytes: A potential diagnostic marker and a critical contributor to the pathogenesis of psoriasis. J Autoimmun. 2018 May;89:30-40.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CXCR2

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

myosin light chain 1 (MYL1) Mouse Monoclonal Antibody [Clone ID: OTI3D1]
CF810636 100 µg

myosin light chain 1 (MYL1) Mouse Monoclonal Antibody [Clone ID: OTI3D1]

Sign In for Pricing
View Details
Colloidal Gold Conjugated Amaranthus caudatus Lectin (Tassel flower, Inca wheat) -ACA-,  5nm
GP-8201-5 1 mL

Colloidal Gold Conjugated Amaranthus caudatus Lectin (Tassel flower, Inca wheat) -ACA-, 5nm

Sign In for Pricing
View Details
PE/Cyanine7 Anti-Human CD25 Antibody[BC96]
E-AB-F1194H-01 20 Tests

PE/Cyanine7 Anti-Human CD25 Antibody[BC96]

Sign In for Pricing
View Details
PE/Cyanine7 Anti-Human CD25 Antibody[BC96]
E-AB-F1194H-02 100 Tests

PE/Cyanine7 Anti-Human CD25 Antibody[BC96]

Sign In for Pricing
View Details
PE/Cyanine7 Anti-Human CD25 Antibody[BC96]
E-AB-F1194H-03 2x 100 Tests

PE/Cyanine7 Anti-Human CD25 Antibody[BC96]

Sign In for Pricing
View Details
UPK3A (Uroplakin 3A) (Rabbit PAb), CF640R conjugate, 0.1mg/mL
BNC400409-100 1x 100 µL

UPK3A (Uroplakin 3A) (Rabbit PAb), CF640R conjugate, 0.1mg/mL

Sign In for Pricing
View Details