Kahweol

Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

Product Specifications

CAS Number

[6894-43-5]

UNSPSC

12352005

Target

AMPK; Apoptosis

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/kahweol.html

Purity

99.9

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C5=C(OC=C5)C=C2)C[C@@]([C@](CO)(O)C4)([H])CC3

Molecular Formula

C20H26O3

Molecular Weight

314.42

References & Citations

[1]Seo HY, et al. Kahweol decreases hepatic fibrosis by inhibiting the expression of connective tissue growth factor via the transforming growth factor-beta signaling pathway. Oncotarget. 2017 Aug 1;8 (50) :87086-87094.|[2]Baek JH, et al. Kahweol inhibits lipid accumulation and induces Glucose-uptake through activation of AMP-activated protein kinase (AMPK) . BMB Rep. 2017 Nov;50 (11) :566-571.