TNFSF12 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Tumor necrosis factor (ligand) superfamily, member 12

Gene Aliases

APO3L, DR3LG, TWEAK, TNLG4A

Gene ID

8742

Swiss Prot

O43508

Accession Number

NP_003800

Reactivity

Human, Mouse, Horse

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human TNFSF12

Target

TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Partner Proteins

DDIT3; TNFSF13B; LYN; OTUB1; TRAF2; BIRC2; AGGF1; TNFRSF12A; TNFRSF25

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

QEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTRARRA

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Horse: 93%; Human: 100%; Mouse: 75%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

27kDa

Protein Length

249

NCBI Gene Symbol

TNFSF12

Host or Source

Rabbit

Protein Name

Tumor necrosis factor ligand superfamily member 12

Gene Name URL

TNFSF12

Nucleotide Accession Number

NM_003809

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