What is the catalog number for HTR1B antibody - N-terminal region (AVARP13042_T100)?

The catalog number for HTR1B antibody - N-terminal region (AVARP13042_T100) is AVARP13042_T100.

What sizes are available for HTR1B antibody - N-terminal region (AVARP13042_T100)?

HTR1B antibody - N-terminal region (AVARP13042_T100) is available in the following size(s): 100 µL.

Is HTR1B antibody - N-terminal region (AVARP13042_T100) in stock?

HTR1B antibody - N-terminal region (AVARP13042_T100) is currently made to order / not held in immediate stock. Contact us for lead time.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

HTR1B antibody - N-terminal region (AVARP13042_T100)

Selected Variant

AVARP13042_T100

Size: 100 µL

Product Specifications

CAS Number

9007-83-4

Gene Name

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

Gene Aliases

S12, 5-HT1B, HTR1D2, HTR1DB, 5-HT-1B, 5-HT1DB, 5-HT-1D-beta

Gene ID

3351

Swiss Prot

P28222

Accession Number

NP_000854

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human HTR1B

Target

The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.

Partner Proteins

MDFI; HTR1D; HTR1B; HTR1A; GSTK1; NME2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKV

Applications

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1.0 mg/ml

Homology

Human: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

44kDa

Protein Length

390

NCBI Gene Symbol

HTR1B

Host or Source

Rabbit

Protein Name

5-hydroxytryptamine receptor 1B

Gene Name URL

HTR1B

Nucleotide Accession Number

NM_000863

Price

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