What is the catalog number for DOK1?

The catalog number for DOK1 is AVARP09001_P050.

What sizes are available for DOK1?

DOK1 is available in the following size(s): 100 µL.

DOK1 is currently made to order / not held in immediate stock. Contact us for lead time.

DOK1

Product Specifications

Gene Name

Docking protein 1, 62kDa (downstream of tyrosine kinase 1)

Gene Aliases

Pp62, P62DOK

Gene ID

1796

Swiss Prot

Q99704

Accession Number

NP_001372

Reactivity

Human, Horse

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human DOK1

Target

DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.

Partner Proteins

UBC; RASA1; ABL1; CD28; Nck1; Syngap1; INSR; CRKL; BCR; Dlg4; gag-pol; ERBB2; VAV1; SRC; SHC1; PTK6; PIK3R1; ITK; FGR; CRK; ABL2; CBLL1; INPP5D; NCK2; MAP4K4; PTPRH; GRB10; TEC; ITGB2; SH2D1A; FES; PTPN6; ITGB3; PLCG1; LYN; KIT; YES1; RET; LCK; ITGB5; ITG

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

EPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGST

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol