DOK1
Product Specifications
Gene Name
Docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Gene Aliases
Pp62, P62DOK
Gene ID
1796
Swiss Prot
Q99704
Accession Number
NP_001372
Reactivity
Human, Horse
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human DOK1
Target
DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Partner Proteins
UBC; RASA1; ABL1; CD28; Nck1; Syngap1; INSR; CRKL; BCR; Dlg4; gag-pol; ERBB2; VAV1; SRC; SHC1; PTK6; PIK3R1; ITK; FGR; CRK; ABL2; CBLL1; INPP5D; NCK2; MAP4K4; PTPRH; GRB10; TEC; ITGB2; SH2D1A; FES; PTPN6; ITGB3; PLCG1; LYN; KIT; YES1; RET; LCK; ITGB5; ITG
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
EPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGST
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Horse: 84%; Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
53kDa
Protein Length
481
NCBI Gene Symbol
DOK1
Host or Source
Rabbit
Protein Name
Docking protein 1
Gene Name URL
DOK1
Nucleotide Accession Number
NM_001381
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