CDKN1B Antibody - C-terminal region
Product Specifications
Gene Name
Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene Aliases
KIP1, MEN4, CDKN4, MEN1B, P27KIP1
Gene ID
1027
Swiss Prot
P46527
Accession Number
NP_004055
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human CDKN1B
Target
CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Partner Proteins
CCND1; UBC; SGK1; PSMB1; CDK4; SKP2; CDK5; CDK3; CDK2; CDK1; SKP1; CKS1B; CCNE1; CCND3; CAMK1; YWHAQ; CCNA2; ABL1; TSC2; LYN; STMN1; RHOA; RPS6KA1; IRF1; KPNA6; CCNE2; CCNA1; VCP; SRC; MAPK10; MAPK8; CDC34; CDK6; RCHY1; COPS5; CUL1; HIST1H1A; CUL4A; JAK2
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
EQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRR
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
22kDa
Protein Length
198
NCBI Gene Symbol
CDKN1B
Host or Source
Rabbit
Protein Name
Cyclin-dependent kinase inhibitor 1B
Gene Name URL
CDKN1B
CAS Number
9007-83-4
Nucleotide Accession Number
NM_004064
Curated Selection
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