CDKN1B Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Gene Aliases

KIP1, MEN4, CDKN4, MEN1B, P27KIP1

Gene ID

1027

Swiss Prot

P46527

Accession Number

NP_004055

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human CDKN1B

Target

CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

CCND1; UBC; SGK1; PSMB1; CDK4; SKP2; CDK5; CDK3; CDK2; CDK1; SKP1; CKS1B; CCNE1; CCND3; CAMK1; YWHAQ; CCNA2; ABL1; TSC2; LYN; STMN1; RHOA; RPS6KA1; IRF1; KPNA6; CCNE2; CCNA1; VCP; SRC; MAPK10; MAPK8; CDC34; CDK6; RCHY1; COPS5; CUL1; HIST1H1A; CUL4A; JAK2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

EQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRR

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol