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CCND3 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Cyclin D3

Gene ID

896

Swiss Prot

P30281

Accession Number

NP_001751

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human CCND3

Target

CCND3 encodes a protein that belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.

Partner Proteins

POLR3GL; TFIP11; CDKN1A; CDK6; CDK4; CDK5; MCM10; CDKN1B; CDK2; CDK11B; FAS; SIL1; EIF3K; ATF5; VDR; MAPK6; NME1; MYB; GC; ETV1; RBL2; POLD1; CDK14; APP; RB1; UBC; PPP1CC; PPP1CB; PPP1CA; NCOA2; MAF1; NPDC1; DMTF1; CRABP2; RARA; DTNBP1; AKAP8; EFEMP2; CAS

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

CQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL

Applications

IHC, WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 92%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Sheep: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

33kDa

Protein Length

292

NCBI Gene Symbol

CCND3

Host or Source

Rabbit

Protein Name

G1/S-specific cyclin-D3

Gene Name URL

CCND3

Nucleotide Accession Number

NM_001760

Frequently Asked Questions

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