FADD Antibody - C-terminal region
Product Specifications
CAS Number
9007-83-4
Gene Name
Fas (TNFRSF6) -associated via death domain
Gene Aliases
GIG3, MORT1
Gene ID
8772
Swiss Prot
Q13158
Accession Number
NP_003815
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human FADD
Target
The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.
Partner Proteins
CFLAR; CASP10; CASP8; ATG5; ATG12; TNF; TRADD; UBC; RIPK1; FAS; TNFSF10; SPOP; TNFRSF1A; MYD88; TNFRSF10A; TNFRSF10B; MKRN1; RIPK3; CUL3; TRAF2; PARK7; FASLG; LRRK2; IKBKG; BMX; FAF1; EDAR; DAPK1; CLIP3; DAXX; TNFAIP3; MAVS; KHDRBS1; TAB1; EZR; TRIM21; IR
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
AHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEAS
Applications
IHC, WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
23kDa
Protein Length
208
NCBI Gene Symbol
FADD
Host or Source
Rabbit
Protein Name
Protein FADD
Gene Name URL
FADD
Nucleotide Accession Number
NM_003824
Curated Selection
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