NLRC4 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

NLR family, CARD domain containing 4

Gene Aliases

CLAN, IPAF, AIFEC, CLAN1, CLANA, CLANB, CLANC, CLAND, FCAS4, CARD12, CLR2.1

Gene ID

58484

Swiss Prot

Q9NPP4

Accession Number

NP_067032

Reactivity

Human, Mouse, Rat, Guinea Pig

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human NLRC4

Target

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs) . Human Ced4 homologs include APAF1, NOD1, and NOD2. These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs) . CARD12 is a member of the Ced4 family and can induce apoptosis.

Partner Proteins

UBC; XK; ALB; NLRC4; PSMC5; CASP8; NLRP4; PYCARD; NOD2; BCL10; CASP1; NLRP1; NLRP3; NOD1; NAIP

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

QLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQV

Applications

IHC, WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Guinea Pig: 80%; Human: 100%; Mouse: 86%; Rat: 80%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

116kDa

Specificity

This antibody will recognize NLRC4 isoform 1 (116kD) and isoform 2 (40kD) .

Protein Length

1024

NCBI Gene Symbol

NLRC4

Host or Source

Rabbit

Protein Name

NLR family CARD domain-containing protein 4

Gene Name URL

NLRC4

Nucleotide Accession Number

NM_021209

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