PPP3CA Antibody - C-terminal region
Product Specifications
Gene Name
Protein phosphatase 3, catalytic subunit, alpha isoform
Gene Aliases
C, CN, CnA, Caln, Calna, 2900074D19Rik
Gene ID
19055
Swiss Prot
P63328
Accession Number
NP_001280551.1
Reactivity
Mouse
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of mouse PPP3CA
Target
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity) . In response to increased Ca2+Â levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity) . In response to increased Ca2+Â levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (By similarity) . Dephosphorylates heat shock protein HSPB1 (By similarity) . Dephosphorylates and activates transcription factor NFATC1 (By similarity) . Dephosphorylates and inactivates transcription factor ELK1 (By similarity) . Dephosphorylates DARPP32 (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
EEAKGLDRINERMPPRRDAMPSDANLNSINKALASETNGTDSNGSNSSNI
Applications
WB
Purification
Affinity purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
57 kDa
Protein Length
521
NCBI Gene Symbol
PPP3CA
Host or Source
Rabbit
Protein Name
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Gene Name URL
PPP3CA
CAS Number
9007-83-4
Nucleotide Accession Number
NM_001293622.1
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