Gnas Antibody-N-terminal region
Product Specifications
CAS Number
9007-83-4
Gene Name
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Gene Aliases
G, N, P, Ga, Gn, P1, P2, P3, XL, GSP, Gs-, Gsa, Nes, Oed, POH, SCG, GPSA, Nesp, SCG6, Gnas1, Nespl, PHP1A, PHP1B, Gnasxl, Nesp55, Oedsml, Galphas, Oed-Sml, Gs-alpha, 5530400H20Rik, A930027G11Rik, C130027O20Rik
Gene ID
14683
Swiss Prot
P63094
Accession Number
NP_001070978.1
Reactivity
Mouse
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of mouse GNAS
Target
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined.
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
NSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKST
Applications
WB
Purification
Affinity purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
43 kDa
Protein Length
394
NCBI Gene Symbol
GNAS
Host or Source
Rabbit
Protein Name
Protein ALEX; protein GNAS; protein SCG6 (secretogranin VI)
Gene Name URL
GNAS
Nucleotide Accession Number
NM_001077510.4
Frequently Asked Questions
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