TOP3B Antibody - middle region (ARP85799_P050)
Product Specifications
Gene Name
Topoisomerase (DNA) III beta
Gene Aliases
TOP3B1
Gene ID
8940
Swiss Prot
O95985-3
Accession Number
NP_001269041.1
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human TOP3B
Target
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
YWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEY
Applications
WB
Purification
Affinity purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
77 kDa
Protein Length
707
NCBI Gene Symbol
TOP3B
Host or Source
Rabbit
Protein Name
DNA topoisomerase 3-beta-1
Gene Name URL
TOP3B
CAS Number
9007-83-4
Nucleotide Accession Number
NM_001282112.1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTR15180875 1 Vial
Lentiviral mouse A530064D06Rik shRNA (UAS) - Lentiviral mouse A530064D06Rik shRNA (UAS, RFP) (25)
Ask
View Details 
MBS7166871 Inquire
Rabbit anti-Escherichia coli O1:K1/APEC HTPG Polyclonal Antibody
Ask
View Details