What is the catalog number for TAB1 Antibody - C-terminal region (ARP81019_P050)?

The catalog number for TAB1 Antibody - C-terminal region (ARP81019_P050) is ARP81019_P050.

What sizes are available for TAB1 Antibody - C-terminal region (ARP81019_P050)?

TAB1 Antibody - C-terminal region (ARP81019_P050) is available in the following size(s): 100 µL.

Is TAB1 Antibody - C-terminal region (ARP81019_P050) in stock?

TAB1 Antibody - C-terminal region (ARP81019_P050) is currently made to order / not held in immediate stock. Contact us for lead time.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

TAB1 Antibody - C-terminal region (ARP81019_P050)

Selected Variant

ARP81019_P050

Size: 100 µL

Product Specifications

CAS Number

9007-83-4

Gene Name

TGF-beta activated kinase 1/MAP3K7 binding protein 1

Gene Aliases

3'-Tab1, MAP3K7IP1

Gene ID

10454

Swiss Prot

Q59FT7

Accession Number

NP_006107.1

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human TAB1

Target

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

MPSQGQMVNGAHSASTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGG

Applications

Purification

Affinity purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

71 kDa

Protein Length

648

NCBI Gene Symbol

TAB1

Host or Source

Rabbit

Protein Name

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Gene Name URL

TAB1

Nucleotide Accession Number

NM_006116.2

Price

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