AP-18
AP-18, a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 reverses complete Freund's adjuvant (CFA) -induced mechanical hyperalgesia in mice. AP-18 attenuated 30 μM AITC-induced Yo-Pro uptake in a concentration-dependent manner, with an IC50 of 10.3 μM[1][2][3].
Product Specifications
CAS Number
55224-94-7
UNSPSC
12352005
Hazard Statement
H302
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ap-18.html
Purity
99.61
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC1=CC=C(/C=C(C)/C(C)=N/O)C=C1
Molecular Formula
C11H12ClNO
Molecular Weight
209.67
Precautions
H302
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPA1
Available Sizes
Frequently Asked Questions
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