What is the catalog number for UIMC1 Antibody - middle region (ARP75596_P050)?

The catalog number for UIMC1 Antibody - middle region (ARP75596_P050) is ARP75596_P050.

What sizes are available for UIMC1 Antibody - middle region (ARP75596_P050)?

UIMC1 Antibody - middle region (ARP75596_P050) is available in the following size(s): 100 µL.

Is UIMC1 Antibody - middle region (ARP75596_P050) in stock?

UIMC1 Antibody - middle region (ARP75596_P050) is currently made to order / not held in immediate stock. Contact us for lead time.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

UIMC1 Antibody - middle region (ARP75596_P050)

Product Specifications

CAS Number

9007-83-4

Gene Aliases

RAP80, X2HRIP110

Gene ID

51720

Swiss Prot

Q96RL1

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of Human UIMC1

Target

UIMC1 is a ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. It plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) . The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. It also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. It may interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. And it may indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

Partner Proteins

HIST2H2AC; UBC; FANCG; RPS6; HSPA4; CDK1; C1QBP; BRCA1; FAM175A; BRCC3; ELC1; ELA1; BLM; SKIL; SUMO1; SUMO2; MDC1; PAXIP1; Cep57; BRE; HIST2H2BE; ESR1; ATP8A2; KIAA0368; RBBP8; RAD23A; BABAM1; TP53; MDM2; SSU72; FAM175B; ERP44; G3BP1; G3BP2; SPATA2; BAG5

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

GEQASEKNECISEDMGDEDKEERQESRASDWHSKTKDFQESSIKSLKEKL

Applications

Purification

Affinity purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol