PNPH Antibody - middle region (ARP75005_P050)
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Product Specifications
CAS Number
9007-83-4
Gene Name
Purine nucleoside phosphorylase
Gene Aliases
NP, PUNP, PRO1837
Gene ID
4860
Swiss Prot
P00491
Accession Number
NP_000261
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human PNPH
Target
This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
Partner Proteins
PNP; UBC; SUMO2; PPME1; SBDS; PSAT1; GMPS; RAB1A; PSMD5; MTAP; ENO2; HECW2; ITGA4; NADK2; TMEM177; DNAJB11; NDUFV1; GLO1; UBD; CDK2; SIRT7; UCHL5; LRIF1; CCDC90B; RBM48; ZHX1; TFB2M; NCALD; TFAM; TP53; APLP1
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
IMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTW
Applications
WB
Purification
Affinity purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
31kDa
Protein Length
289
NCBI Gene Symbol
PNP
Host or Source
Rabbit
Protein Name
Purine nucleoside phosphorylase
Gene Name URL
PNP
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