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HRAS Antibody - C-terminal region

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Product Specifications

CAS Number

9007-83-4

Gene Name

HRas proto-oncogene, GTPase

Gene Aliases

CTLO, HAMSV, HRAS1, RASH1, p21ras, C-H-RAS, H-RASIDX, C-BAS/HAS, C-HA-RAS1

Gene ID

3265

Swiss Prot

P01112

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human RASH

Target

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

Partner Proteins

RIN1; LGALS1; ABL2; DAB2IP; RASSF5; RAF1; KRT18; SLC9A3R2; TPR; PSMB2; NEDD8; ZHX2; LATS2; PPP1R13B; TP53; RNF115; BRAP; CBL; SPRY2; UBC; SH3KBP1; RABGEF1; BTRC; DEAF1; RGL1; RALGDS; RGL2; GRIN1; ZBTB12; RIT2; RASSF2; RASIP1; TTC1; RAP1GDS1; RGL4; RASGRP4

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

QDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG

Applications

WB

Purification

Affinity purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

20kDa

Protein Length

189

NCBI Gene Symbol

HRAS

Host or Source

Rabbit

Protein Name

GTPase HRas

Gene Name URL

HRAS

Frequently Asked Questions

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