4EBP1 Antibody - C-terminal region (ARP74511_P050)

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Product Specifications

CAS Number

9007-83-4

Gene Name

Eukaryotic translation initiation factor 4E binding protein 1

Gene Aliases

BP-1, 4EBP1, 4E-BP1, PHAS-I

Gene ID

1978

Swiss Prot

Q13541

Accession Number

NP_004086

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human 4EBP1

Target

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Partner Proteins

Mtor; MLST8; RPTOR; TCF4; REL; EIF4E; RICTOR; MAPKAP1; UBC; SLMAP; LATS1; PRKDC; ATM; PPP2R4; STK3; MAPK14; LRRK2; AGO2; MAPK1; KLHL25; IRAK4; PRKCA; GSK3B; CHTF8; RHEBL1; RPS6KB1; MAPKAPK5; PPP2CA; RPS6KA5; EIF4E2; MVD; RORC; BUB1; AKT1; CSNK2A2; CSNK2A1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

NSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQ

Applications

Purification

Affinity purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol