PTK2B Antibody - middle region
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Product Specifications
CAS Number
9007-83-4
Gene Name
Protein tyrosine kinase 2 beta
Gene Aliases
PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK
Gene ID
2185
Swiss Prot
Q14289-2
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human FAK2
Target
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
Partner Proteins
CBLB; UBC; EGFR; PXN; HSP90AA1; MAPT; GP6; TRAF4; BCAR1; SKAP2; GP1BB; UL49; SOCS3; SRC; GRB2; FYN; DNM1; ALG2; SH3KBP1; PDCD6IP; CBL; SOCS2; PTEN; MBD2; DLGAP3; STAP1; SORBS2; NEDD9; EFS; NPHP1; PITPNM2; PITPNM3; PITPNM1; ARHGAP21; RB1CC1; ASAP1; LPXN; P
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
TPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQEEDFIQPSSREE
Applications
WB
Purification
Affinity purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
106kDa
Protein Length
967
NCBI Gene Symbol
PTK2B
Host or Source
Rabbit
Protein Name
Protein-tyrosine kinase 2-beta
Gene Name URL
PTK2B
Frequently Asked Questions
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