KDM5B Antibody - C-terminal region
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Product Specifications
CAS Number
9007-83-4
Gene Aliases
CT31, PLU1, PUT1, MRT65, PLU-1, JARID1B, PPP1R98, RBP2-H1, RBBP2H1A
Gene ID
10765
Swiss Prot
Q9UGL1
Accession Number
NP_006609
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human KDM5B
Target
KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
Partner Proteins
FBXW11; UBC; HDAC2; HDAC4; SUMO1; SUMO3; PPP1CA; TFAP2C; MYC; HDAC7; HDAC5; NCOR1; PAX9; HDAC1; ELAVL1; CHD3; MTA3; MBD3; KDM1A; MTA2; MBD2; RBBP7; RBBP4; RB1; SUMO2; KLF10; LMO2; FOXG1; AR; VGLL3; PRDM13; ARID1B; BMP2K; RNF43; RBM15B; DBNL; CECR6; SLC39A
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
EMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQ
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
169kDa
Protein Length
1544
NCBI Gene Symbol
KDM5B
Host or Source
Rabbit
Gene Name URL
KDM5B
Frequently Asked Questions
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