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FBXL15 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Aliases

JET, PSD, Fbl15, FBXO37

Gene ID

79176

Swiss Prot

Q9H469

Accession Number

NP_077302

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N-terminal region of Human FBXL15

Target

FBXL15 is a substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance and also mediates ubiquitination of SMURF2 and WWP2.

Partner Proteins

HNRNPD; SKP1; ITCH; SMURF2; HECW2; SMURF1; NEDD4L; HECW1; WWP2; WWP1; RBX1; CUL1; NEDD4; HSP90AA1; COPS6; UBC

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

PPMEPSGGEQEPGAVRFLDLPWEDVLLPHVLNRVPLRQLLRLQRVSRAFR

Applications

WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Goat: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 86%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

32kDa

Protein Length

300

NCBI Gene Symbol

FBXL15

Host or Source

Rabbit

Protein Name

F-box/LRR-repeat protein 15

Gene Name URL

FBXL15

Nucleotide Accession Number

NM_024326

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