SPRTN Antibody - C-terminal region
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Product Specifications
CAS Number
9007-83-4
Gene Aliases
DVC1, PRO4323, spartan, C1orf124
Gene ID
83932
Swiss Prot
Q9H040
Accession Number
NP_114407
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human SPRTN
Target
SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
Partner Proteins
H2BFS; UBR5; FAM120A; STRAP; CKAP4; MAGED2; HIST2H2BF; HIST1H2BK; POLD4; ZC3HAV1; POLD3; DDX17; SYNCRIP; TRIM28; LRPPRC; HUWE1; HNRNPDL; AKAP12; RBM39; H1FX; HIST1H2BH; HIST1H2BM; HIST1H2BN; HIST1H2BL; HIST1H2BG; VIM; VDAC1; UBB; TUFM; DNAJC7; TMPO; STAU1
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
QIKSSGNDPKYSTTTAQNSSSSSSQSKMVNCPVCQNEVLESQINEHLDWC
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
55 kDa
Protein Length
489
NCBI Gene Symbol
SPRTN
Host or Source
Rabbit
Protein Name
SprT-like domain-containing protein Spartan
Gene Name URL
SPRTN
Nucleotide Accession Number
NM_032018
Curated Selection
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