MYSM1 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Aliases

2ADUB, BMFS4, 2A-DUB

Gene ID

114803

Swiss Prot

Q5VVJ2

Accession Number

NP_001078956

Reactivity

Human, Dog, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human MYSM1

Target

MYSM1 is a metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. It preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. MYSM1 acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR) -induced gene activation.

Partner Proteins

UBC; DICER1; SUMO2; TUBB1; WDR77; STK38; PRMT5; KAT2B; HIST2H2AC; RBM10; KIF11; HSPA1A; HNRNPH1; EEF1A1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

CLQKLLECMRKTLSKVTNCFMAEEFLTEIENLFLSNYKSNQENGVTEENC

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Dog: 86%; Human: 100%; Rabbit: 77%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

91kDa

Protein Length

828

NCBI Gene Symbol

MYSM1

Host or Source

Rabbit

Protein Name

Histone H2A deubiquitinase MYSM1

Gene Name URL

MYSM1

Nucleotide Accession Number

NM_001085487

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