SPG21 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Spastic paraplegia 21 (autosomal recessive, Mast syndrome)

Gene Aliases

MAST, ACP33, GL010, ABHD21, BM-019

Gene ID

51324

Swiss Prot

Q9NZD8

Accession Number

NP_057714

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human SPG21

Target

The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene.

Partner Proteins

INCA1; SPRED2; DTX3L; CMTM5; TRIM9; DTX2; REEP6; FAM114A1; ATPAF2; EFHC2; CCDC33; CCDC102B; TRIM54; AGTRAP; CTPS2; S100B; PRPS1; KRT15; CRYAA; TRIM23; CUTC; ARL6IP1; IKZF3; MID2; RABAC1; TFG; TRAF2; TRAF1; TCF12; TCF4; UBC; GSK3A; DHX40; YLPM1; HMGCS1; AK

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

LCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 93%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 93%; Rabbit: 79%; Rat: 86%; Sheep: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

35kDa

Protein Length

308

NCBI Gene Symbol

SPG21

Host or Source

Rabbit

Protein Name

Maspardin

Gene Name URL

SPG21

Nucleotide Accession Number

NM_016630

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