Vicriviroc (maleate)
Product Specifications
UNSPSC Description
Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU?570).
Target Antigen
CCR; HIV
Type
Reference compound
Related Pathways
Anti-infection;GPCR/G Protein;Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/Vicriviroc-maleate.html
Solubility
DMSO : 50 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic;warming)
Smiles
CC1(N2C[C@H](C)N([C@H](C3=CC=C(C(F)(F)F)C=C3)COC)CC2)CCN(C(C4=C(C)N=CN=C4C)=O)CC1.O=C(O)/C=C\C(O)=O
Molecular Weight
649.70
References & Citations
[1]Tagat JR, et al. Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist. J Med Chem. 2004 May 6;47(10):2405-8.|[2]Strizki JM, et al. Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2005 Dec;49(12):4911-9.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-17377/Vicriviroc-maleate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-17377/Vicriviroc-maleate-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
599179-03-0
Available Sizes
Curated Selection
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